In this article there were developed the technology for obtaining a dry extract of a urological collection for the first time, the influence of extraction conditions depending on temperature, the degree of grinding of raw materials, the type of extractant, the ratio of raw materials and extractants has been investigated. As a result of the studies, it was proved that when obtaining a dry extract of urological collection, the grinding of raw materials should be 2-3 mm, purified water is recommended as an extractant, the hydromodule is 1:30, t = 70-800C, the extraction time is 120 minutes, the method is maceration.

Various enterprises of JSC “Samarkandkimyo”, which produce a wide variety of ammonium and nitrate saltpeter, are sources of nitrogen, phosphorus, potassium, and ammonium ecotoxicants in the republic. Phosphate manufacture in Uzbekistan, such as superphosphates, hexachlorobutadiene, tri- and tetrachlorethylene, and others, are sources of nitrogen-phosphorus-potassium and ammonium toxicants. JSC “Samarkandkimyo” (petrochemical complex in the city’s industrial zone) is one of Uzbekistan’s largest enterprises for the production of nitrogen and phosphorus-containing fertilizers of the 2.4-D group, which are among the most effective and widely used, as well as the country’s main supplier of nitrogen-phosphorus-potassium and ammonium xenobiotics.

Dioxins, which are considered by many researchers as worldwide superecotoxicants with a broad spectrum of biological activity in extremely low levels on all living things, are formed in tandem with the production of nitrogen-phosphorus nitrate. Dioxins are very harmful for people since they are stable in the environment due to accumulation and have a large potential for entering the body. The personnel of the enterprise (part of JSC “Samarkandkimyo”) which manufactures ammonium and nitrate saltpeter (ammophos, nitrophos) were examined. The age of workers in production ranged from 20 to 55 years, of whom 53 were men, 48 women; work experience in these industries ranged from 1 to 35 years.

As a control group, a voluntary group of 100 patients, comparable in age and sex to the main group, who sought dental care at the Samarkand Regional Dental Clinic but did not come into contact with dangerous substances such as nitrogen-phosphorus-potassium and ammonium compounds, were studied.

This article provides a literature review of the latest data collected on the epidemiology, pathogenesis and course of the novel coronavirus infection COVID-19 and its manifestations in the oral cavity. The transmission routes of the disease and the main symptoms are also described. The article describes the current pandemic situation caused by the action of the SARS-CoV-2 virus, which is responsible for the outbreak of the infectious disease COVID-19 in Uzbekistan.

The aim of the study was to study the role of brain sodium uretic peptide in the diagnosis of chronic heart failure in patients with type 2 diabetes mellitus. For the period 2019-2021, we identified and selected 185 patients as an object of research based on the materials of their appeal to medical institutions in Andijan aged 30 and older.  The patients underwent general clinical, biochemical, hormonal, genetic blood tests, as well as ECG, Echo-ECG and other instrumental studies. The mean values of NT proBNP significantly differed in all groups and, at the same time, they were significantly higher in the group of patients with diabetes mellitus + CHF compared to those in patients with isolated CHF. We selected median NT-proBNP levels in increasing NT-proBNP tertiles in the range from 125 to 250 pg / ml, from 250 to 500 pg / ml, and above 500 pg / ml.  The dynamics of their concentration, mainly NT-proBNP, can help in assessing the effectiveness of the therapy and the need for dose titration of drugs.