Medical Sciences
| Open Access |
Vol. 2 No. 05 (2022): Volume02 Issue05
| DOI:
https://doi.org/10.37547/medical-fmspj-02-05-03
STUDY THE ANTIFIBROUS EFFICACY OF PLANT PROANTHOCYANIDIN IN RATS WITH CHRONIC HELIOTRINE LIVER DAMAGE
A.N. Aripov , Doctor of Medical Sciences, Professor, Head of the Department of Clinical Laboratory diagnostics of Republican Specialized Scientific and Practical Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan O.A. Aripov , Doctor of Medical Sciences, Professor, Senior Researcher of the Department of Clinical Laboratory diagnostics of Republican Specialized Scientific and Practical Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan L.L. Akhunjanova , Candidate of Biological Sciences, Senior Researcher of the Department of Clinical Laboratory diagnostics of Republican Specialized Scientific and Practical Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan A.O. Nabiev , Junior Researcher of the Department of Clinical Laboratory diagnostics of Republican Specialized Scientific and Practical Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan D.A. Nabieva , Doctor of Medical Sciences, Senior Researcher of the Department of Clinical Laboratory diagnostics of Republican Specialized Scientific and Practical Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan T.T. Khamroev , Junior Researcher of the Department of Pharmacology and Toxicology of the Institute of Plant Chemistry named after Academician S.Yu.Yunusov of the Academy of Sciences of the Republic of UzbekistanAbstract
Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of the blood, as well as the amount of NO – nitrates (in connection with lipoproteins), proteins in the blood against the background of heliotrine liver damage was studied. At the same time, yantacin demonstrated a significant protective effect compared to the control group on the detected fibrosis, according to which certain indicators, against the background of chronic toxic liver damage. In this regard, a more extensive in-depth study of the effect of the studied substance plant proanthocyanidin on normal and impaired liver activity is carried out.
Keywords
Heliothrin, fibrosis and cirrhosis of the liver, hepatoprotective, antifibrotic
References
Aripov A.N., Akhunjanova L.L., Khamroev T.T. Differential Analysis of Chronic Toxic Hepatitis Caused by The Introduction of Heliotrin Solution in Various Ways. Texas Journal of Medical Science. A Bi-Monthly, Peer Reviewed International Journal page 58-62 Volume 4 .27.01.2022.
WHO Global hepatitis report, 2017.
WHO Global hepatitis report, Amsterdam, 2018.
Ивашкин В.Т., Маевская М.В. Лечение осложнений цирроза печени. М.: Литтерра, 2011.
Soriano1, V Report from the International Conference on Viral Hepatitis -2017/ Vicente Soriano1, Benjamin Young and Nancy Reau // AIDS reviews January 2018 DOI: 10.24875/AIDSRev.M17000012.
Zou G.A., Mansur S., Hu S.C., Aisa H.A., Shakhidoyatov Kh.M. Chemistry of Natural Compounds, 2012, vol. 48 (4),pp. 635–637.
Фесенко Л.М., Арипов А.Н..Ахунджанова Л.Л. Экспериментальное обоснование антифиброзной эффективности янтацина в печени крыс с хронической гелиотриновой интоксикацией. Научно-практический журнал Педиатрия №3/2019. С.211-215.
Абдуллаев Н.Х., Каримов Х.Я. Печень при интоксикациях гепатотропными ядами. – Ташкент: Медицина, 1989. – 98 с.
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Copyright (c) 2022 A.N. Aripov, O.A. Aripov, L.L. Akhunjanova, A.O. Nabiev, D.A. Nabieva, T.T. Khamroev
This work is licensed under a Creative Commons Attribution 4.0 International License.