This study explores how knowledge bridging facilitates the formation and sustainability of collaborative innovation ecosystems in interdisciplinary domains. As complex global challenges increasingly demand cross-sectoral and cross-disciplinary solutions, effective knowledge integration becomes vital. Through a combination of qualitative case studies and network analysis, the research identifies key mechanisms—including boundary-spanning roles, shared platforms, and co-creation processes—that enable diverse stakeholders such as academia, industry, and government to synergize knowledge. Findings reveal that dynamic knowledge flows, mutual trust, and institutional support are critical to fostering innovation and adaptability within these ecosystems. The study offers a strategic framework for designing and managing interdisciplinary collaborations aimed at driving innovation across complex knowledge frontiers.