The development of fast disintegrating films and tablets for the delivery of Valsartan, an angiotensin II receptor antagonist used in the treatment of hypertension, aims to improve patient compliance, especially for those with difficulty swallowing conventional tablets. This study focuses on the formulation, characterization, and evaluation of fast disintegrating films and tablets of Valsartan using various excipients such as superdisintegrants, polymers, and other film-forming agents. The fast disintegrating films were prepared using solvent casting techniques, while tablets were formulated through direct compression. The formulations were evaluated for disintegration time, drug release profile, mechanical strength, and stability under various conditions. The Valsartan-loaded films and tablets exhibited rapid disintegration, with improved drug release kinetics compared to traditional tablet formulations. Additionally, the film dosage form demonstrated excellent patient acceptability due to its ease of administration. In vitro drug release studies showed that both the films and tablets achieved complete release within 10–15 minutes, ensuring fast onset of action. Stability studies indicated that the formulations remained stable under accelerated conditions, ensuring the feasibility of these fast-dissolving forms for clinical application. This research highlights the potential of fast disintegrating films and tablets as an effective alternative to conventional Valsartan formulations, offering benefits in terms of ease of administration, improved bioavailability, and enhanced patient compliance.

Valsartan, Fast disintegrating films, Fast disintegrating tablets

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