Articles | Open Access | Vol. 4 No. 11 (2024): Volume 04 Issue 11

EXPLORING THE GENETIC LANDSCAPE OF THROMBOSIS RISK IN A SAMPLE OF THE IRAQI POPULATION

Abbas Darwish , Department of Medical Biotechnology/College of Biotechnology/Al-Nahrain University/ Baghdad/ Iraq

Abstract

Thrombosis is a significant health concern globally, with genetic factors contributing to its development. This study aims to explore the genetic landscape associated with thrombosis risk in a sample of the Iraqi population. Using a case-control design, we analyzed genetic polymorphisms linked to thrombosis, including variations in genes related to coagulation, inflammation, and endothelial function. A total of 300 participants, including 150 individuals with a confirmed history of thrombosis and 150 matched controls, were recruited for this study. Genotyping was performed using polymerase chain reaction (PCR) and sequencing techniques to identify relevant genetic variants. The results revealed several significant associations between specific genetic polymorphisms and increased thrombosis risk in the Iraqi population. Additionally, environmental factors and their interaction with genetic predispositions were examined to provide a comprehensive understanding of thrombosis risk. These findings highlight the importance of genetic screening in identifying individuals at risk of thrombosis and contribute to the growing body of literature on the genetic epidemiology of thrombotic disorders in diverse populations.

Keywords

Thrombosis, Genetic risk factors, Iraqi population

References

Ali N, Hedyeh F T, Mohammad N, Sadaf T,Maryam J H, Fahimeh S T and Seyed R S(2013), “Screening for mutations in 10 exonsof the coagulation factor gene”, EuropeanJ.biology., Vol. 3, No. 3, pp. 589-592.

Asselta R and Peyvandi F (2009), Factor Vdeficiency SeminThrombHemost ., Vol. 35,No. 4, pp. 382-9.

Asselta R, Tenchini M L and Duga S (2006),“Inherited defects of coagulation factor V: thehemorrhagic side”, J.ThrombHaemost., Vol.4, No. 1, pp. 26-34.

Castoldi E, Simioni P, Kalafatis M, LunghiB, Tormene D, Girelli D, Girolami Aand Bernardi F (2000), “The prothrom-binase complex in a thrombophilic family”,Blood, Vol. 15, No. 4, pp. 1443-8.

Freeman W and Company H (2000).,Genetic Analysis, ISBN., 978(1):4180-5357.

Greer I A (2003), Best Pract Res Clin ObstetGynaecol., Vol. 17, No. 3, pp. 413-25.

7. Huang D D, Wang X F and Chen H Y (2010),“Analysis of phenotype and genotype in fourChinese pedigrees with inheritedcoagulation factor V deficiency”,ZhonghuaXue YeXueZaZhi, Vol. 31, p. 149.

Kumar and Vinay (2007), Robbins BasicPathology, Philadelphia: Saunders/Elsevier.ISBN: 978(1):4160-2973.

Lewis R (2004), Human Genetics:Concepts and Applications, 6th ed., McGrawHill. ISBN., 0072951745.

Ossowski S, Schneeberger K and Lucas-Lledó J I (2010), “The rate and molecularspectrum of spontaneous mutations”,Science., Vol. 1, No. 5961, pp. 92-4.

Press R D, Bauer K A, Kujovich J L, Heit J A(2002), Arch Pathol Lab Med., Vol. 126, No.11, pp. 1304-18.

Ren H (2005), “BAC-based PCR fragmentmicroarray: high-resolution detection ofchromosomal deletion and duplicationbreakpoints”, Human Mutations., Vol. 25,No. 5, pp. 476–482.

Rosendaal F R and Reitsma P H (2009),“Genetics of venous thrombosis”,J.ThrombHaemost., Vol. 1, pp. 301-4.

Saladin and Kenneth S (2012), “Anatomy &Physiology: The Unity of Form andFunction”, 6th ed., McGraw-Hill., p. 710.

Sawyer, Stanley A, Parsch J and Zhi Z(2007), “Prevalence of positive selectionamong nearly neutral amino acidreplacements in Drosophila”, Proc. Natl.Acad. Sci. U.S.A. (Washington, DC: National Academy of Sciences)., Vol. 104,No. 16, pp. 6504–6510.

Shinozawa K, Amano K and Suzuki T(2007), “Molecular characterization of 3factor V mutations, R2174L, V1813M, anda 5-bp deletion that cause factor Vdeficiency”, Int.J.Hematol., Vol. 86, pp. 407.

Ungprasert P, Ratanapo S andCheungpasitporn W (2013), “Managementin Thoracic Aorta Mural Thrombi: EvidenceBased Medicine and Controversy”,Emergency Medicine., Vol. 104, pp. 2165-7548.

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Abbas Darwish. (2024). EXPLORING THE GENETIC LANDSCAPE OF THROMBOSIS RISK IN A SAMPLE OF THE IRAQI POPULATION. Frontline Medical Sciences and Pharmaceutical Journal, 4(11), 1–7. Retrieved from https://www.frontlinejournals.org/journals/index.php/fmspj/article/view/615