Brain aging is a complex process characterized by cognitive decline and neuronal deterioration, often exacerbated by oxidative stress and inflammation. D-Galactose-induced brain aging is a widely used model to study these effects. This study investigates the protective effects of Alpinia galanga, a medicinal plant known for its antioxidant and anti-inflammatory properties, against D-Galactose-induced brain aging.

In this study, male Wistar rats were administered D-Galactose to induce brain aging, followed by treatment with Alpinia galanga extract. Behavioral assessments, including memory and cognitive function tests, were conducted to evaluate the impact of the treatment. Additionally, biochemical analyses were performed to measure oxidative stress markers, antioxidant enzyme activities, and inflammatory cytokine levels in the brain.

The results demonstrated that Alpinia galanga significantly improved cognitive function and reduced memory deficits in the D-Galactose-treated rats. Furthermore, the extract effectively decreased oxidative stress markers, enhanced antioxidant enzyme activities, and reduced inflammation in the brain tissue. These findings suggest that Alpinia galanga exerts neuroprotective effects, potentially through its antioxidant and anti-inflammatory properties, thereby mitigating D-Galactose-induced brain aging. This study highlights the therapeutic potential of Alpinia galanga as a natural intervention for combating age-related cognitive decline and offers insights into its mechanisms of action in neuroprotection.

Alpinia galanga, brain aging, neuroprotection

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